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Series GSE53877 Query DataSets for GSE53877
Status Public on Nov 17, 2014
Title Wild type and Neuregulin 4 (Nrg4) knockout mouse livers
Organism Mus musculus
Experiment type Expression profiling by array
Summary Nrg4 is a brown fat-enriched adipokine that binds to the liver and preserves metabolic homeostasis during chronic energy excess. Adipose tissue Nrg4 expression is reduced in mouse and human obesity. Nrg4 deficient mice develp more severe insulin resistance and hepatic fat accumulation upon high-fat diet feeding.
We used microarrays to elucidate the metabolic pathways that are regulated by Nrg4 in the liver.
Overall design Wild type and Neuregulin 4 (Nrg4) knockout mice were fed high-fat diet (Research Diets D12492) for eight weeks. Tissues were harvested under ad lib condition for RNA isolation and microarray hybridization using Affymetrix Mouse MG-430 PM Strip arrays. Three independent pools of WT and KO mouse liver RNA were included in the study.
Manuscript title: A brown fat-enriched secreted factor preserves metabolic homeostasis through attenuating hepatic lipogenesis, (journal information TBD)
Contributor(s) Wang GX, Zhao XY, Meng ZX, Kern M, Dietrich A, Chen Z, Cozacov Z, Zhou D, Okunade AL, Su X, Li S, Blüher M, Lin JD
Citation(s) 25401691
Submission date Jan 07, 2014
Last update date Aug 06, 2018
Contact name Jiandie Lin
Phone 734-615-3512
Organization name University of Michigan
Department Life Sciences Institute
Street address 210 Washtenaw Avenue
City Ann Arbor
State/province MI
ZIP/Postal code 48109
Country USA
Platforms (1)
GPL11180 [HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate
Samples (6)
GSM1302482 WT liver, biological rep1
GSM1302483 WT liver, biological rep2
GSM1302484 WT liver, biological rep3
BioProject PRJNA233620

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Supplementary file Size Download File type/resource
GSE53877_RAW.tar 11.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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