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Series GSE54823 Query DataSets for GSE54823
Status Public on Mar 01, 2014
Title WT and FcgKO peritoneal MF response to IL4
Organism Mus musculus
Experiment type Expression profiling by array
Summary Emerging data suggest that many immunoreceptors, all of which use a conserved ITAM-module for their signaling, can couple with members of additional classes of membrane receptors to deliver unique signal(s) to the cell. Using functional and gene expression analysis we describe the role for the tonic signaling through Fcg-chain, the major ITAM-module of the innate immune system, in modifying cytokine responses in MF.
Overall design Peritoneal MF were left unstimulated or were stimulated in duplicates for 6 hrs with IL4. cDNA was analyzed using 8-sample Mouse Ref-8 v2.0 Illumina array. Expressed genes were defined as those with p<0.05, and their relative expression values were calculated using average of two WT unstimulated samples as calibrator.
Contributor(s) Ruslan M
Citation(s) 24608040
Submission date Feb 10, 2014
Last update date Jun 14, 2018
Contact name Ruslan Medzhitov
Organization name Yale University
Department Immunobiology
Street address PO Box 208011 300 Cedar Street TAC S660
City New Haven
State/province CT
ZIP/Postal code 06520
Country USA
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (8)
GSM1324488 WT Unstimulated 1
GSM1324489 FcgKO Unstimulated 1
GSM1324490 WT IL4 stim 1
This SubSeries is part of SuperSeries:
GSE54824 A role for the ITAM signaling module in specifying cytokine receptor functions
BioProject PRJNA237758

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE54823_RAW.tar 3.1 Mb (http)(custom) TAR
GSE54823_non-normalized.txt.gz 1.3 Mb (ftp)(http) TXT
Processed data included within Sample table

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