|
| Status |
Public on Oct 01, 2014 |
| Title |
Genomic analysis of low-grade serous ovarian carcinomas [ILOEF] |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
|
| Summary |
Low-grade serous ovarian carcinomas are typically Ras-pathway mutated, TP53 wild-type, have limited chromosomal aberration, and are frequently associated with borderline tumors. By contrast, high-grade serous ovarian carcinoma lack Ras-pathway mutations, are invariably TP53 mutated, show widespread genomic change, and are commonly BRCA-pathway disrupted.We sought to identify differences in genomic copy number changes between co-existing borderline and invasive components of serous carcinoma.
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| |
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| Overall design |
Paired co-existing borderline and invasive tumor components were sampled and profiled from formalin-fixed paraffin embedded tumors from 6 patients
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| |
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| Contributor(s) |
deFazio A, Bowtell D, Emmanuel C, Etemadmoghadam D, Chiew Y, George J |
| Citation(s) |
25316818 |
| |
| Submission date |
May 05, 2014 |
| Last update date |
Jan 07, 2015 |
| Contact name |
Dariush Etemadmoghadam |
| E-mail(s) |
dariush.etemadmoghadam@petermac.org
|
| Phone |
61396561149
|
| Organization name |
Peter MacCallum Cancer Centre
|
| Street address |
St Andrew's Place
|
| City |
East Melbourne |
| ZIP/Postal code |
3002 |
| Country |
Australia |
| |
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| Platforms (1) |
| GPL18643 |
Illumina HumanOmniExpressFFPE-12 BeadChip |
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| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE57280 |
Genomic analysis of low-grade serous ovarian carcinomas |
|
| Relations |
| BioProject |
PRJNA246156 |
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