|
| Status |
Public on Jul 06, 2021 |
| Title |
Pan-genomic study of primary human retinoblastoma samples |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Genome variation profiling by SNP array
Methylation profiling by genome tiling array
Genome variation profiling by genome tiling array
|
| Summary |
Retinoblastoma is the most common intraocular cancer of infancy and childhood, with an incidence of one case per 15,000 - 20,000 live births. An early event in retinoblastoma genesis is a functional loss of both alleles of the RB1 gene. However, other genes are likely to be involved in the development of this cancer. In this study we sought to build a comprehensive molecular portrait of this cancer by performing transcriptomic, methylomic, as well as genomic profiling of primary retinoblastoma samples. The patients whose tumors were studied had received no treatment prior to surgical enucleation.
This SuperSeries is composed of the SubSeries listed below.
|
| |
|
| Overall design |
Refer to individual Series: 118 samples distincts
Expression profiling by array (62 samples distincts, 66 files with replicates)
Genome variation profiling by SNP array (44 samples by SNP 370k, 22 samples by SNP 610k and 28 samples by Cytoscan)
Methylation profiling by genome tiling array (70 samples distincts, 74 files with replicates)
Genome variation profiling by genome tiling array (51 samples by BAC 3k and 26 samples by BAC 5k)
|
| |
|
| Citation(s) |
34552068 |
| |
| Submission date |
Jun 24, 2014 |
| Last update date |
Mar 02, 2022 |
| Contact name |
Elodie chapeaublanc |
| E-mail(s) |
elodie.chapeaublanc@pasteur.fr
|
| Organization name |
Institut Curie
|
| Department |
UMR 144
|
| Lab |
Equipe Radvanyi
|
| Street address |
26 rue d'ulm
|
| City |
paris |
| ZIP/Postal code |
75248 |
| Country |
France |
| |
|
| Platforms (7)
|
| GPL6985 |
Illumina HumanCNV370-QuadV3 DNA Analysis BeadChip (HumanCNV370-QuadV3_C) |
| GPL8887 |
Illumina Human610-Quad v1.0 BeadChip |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
| GPL16131 |
[CytoScanHD_Array] Affymetrix CytoScan HD Array |
| GPL18861 |
CIT-CGH Homo sapiens BAC [HG19] |
| GPL28718 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG_v23] |
| GPL29807 |
CIT-CGH Homo sapiens BAC 5.3K [HG19] |
|
| Samples (312)
|
|
| This SuperSeries is composed of the following SubSeries:
|
| GSE58780 |
Retinoblastoma gene expression data |
| GSE58781 |
Retinoblastoma SNP array data |
| GSE58783 |
Retinoblastoma genome methylation data |
| GSE58784 |
Retinoblastoma genome variation profiling by genome tiling array |
|
| Relations |
| BioProject |
PRJNA253480 |
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