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Series GSE59612 Query DataSets for GSE59612
Status Public on Jul 22, 2014
Title MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We obtained radiographically-localized biopsies during glioma resection surgeries to sample the tumor core and margins from multiple glioma patients. We also procured fresh, non-neoplastic brain tissue specimens from multiple patients having procedures to relieve epilespy symptoms or to place shunts to treat normal pressure hydrocephalus. We then used RNA-Seq to compare expression patterns between geographically distinct regions of gliomas and computational deconvolution to estimate cell type-specific expression patterns in different disease subtypes.
Overall design RNA-Seq analysis in 39 contrast-enhancing glioma core samples, 36 non-enhancing FLAIR glioma margin samples, and 17 non-neoplastic brain tissue samples.
Contributor(s) Sims PA, Canoll P
Citation(s) 25114226
Submission date Jul 21, 2014
Last update date May 15, 2019
Contact name Peter A Sims
Organization name Columbia University
Street address 3960 Broadway, Lasker 203AC
City New York
State/province NY
ZIP/Postal code 10032
Country USA
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (92)
GSM1440412 BJ003
GSM1440413 BJ007
GSM1440414 BJ008
BioProject PRJNA255754
SRA SRP044668

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE59612_contrast-enhancing_glioma_FPKM.txt.gz 4.4 Mb (ftp)(http) TXT
GSE59612_non-enhancing_glioma_FPKM.txt.gz 4.1 Mb (ftp)(http) TXT
GSE59612_non-neoplastic_brain_FPKM.txt.gz 2.1 Mb (ftp)(http) TXT
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Processed data are available on Series record

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