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Series GSE61970 Query DataSets for GSE61970
Status Public on Sep 21, 2016
Title RRBS assessment of global methylation alterations alterations in Dnmt3aKO/FLT3-ITD leukemia
Organism Mus musculus
Experiment type Methylation profiling by high throughput sequencing
Summary Using RRBS we assessed global DNA methylation changes in two mouse models of oncogenic FLT3-driven leukemia in the presence and absence of Dnmt3a.
Overall design Mouse RRBS DNA methylation maps of Dnmt3aKO/FLT3-ITD leukemias, Dnmt3aKO/FLT3-ITD leukemias overexpressing Dnmt3a or GFP, FLT3-ITD leukemias, normal CD4+/CD8+ thymocytes, Dnmt3aKO thymocytes, heterozygous Dnmt3a/heterozygous Flt3-ITD knockin leukemias, and heterozygous Flt3-ITD knockin pre-leukemic bone marrow cells were obtained by sequencing on Illumina HiSeq 2000 or 2500.
Contributor(s) Rodriguez B, Li W, Goodell M
Citation(s) 27300438
Submission date Oct 01, 2014
Last update date May 15, 2019
Contact name Margaret Goodell
Organization name Baylor College of Medicine
Street address One Baylor Plaza, N1030
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
Platforms (2)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (16)
GSM1517798 WT3a_FLT3_RRBS_1 RRBS
GSM1517799 KO3a_FLT3_RRBS_1 RRBS
GSM1517800 WT3a_FLT3_RRBS_2 RRBS
This SubSeries is part of SuperSeries:
GSE61971 Molecular profiling of mouse Dnmt3a/FLT3-ITD leukemia models
BioProject PRJNA262829
SRA SRP048580

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE61970_RAW.tar 1.2 Gb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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