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Series GSE62288 Query DataSets for GSE62288
Status Public on Oct 15, 2014
Title A Novel Population of Human Cardiac Resident Mesenchymal Stem Cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We describe a novel population of human adult cardiac resident stem cells (CRSCs), which are positive for W8B2 antigen, originating from human adult atrial appendages. W8B2+ CRSCs exhibit a spindle-shaped morphology, are clonogenic and able to self-renew. W8B2+ CRSCs show high expression of mesenchymal but not hematopoietic nor endothelial markers. W8B2+ CRSCs expressed GATA4, HAND2, and TBX5, but not C-KIT, SCA-1, NKX2.5, PDGFRα, ISL1 or Wilm’s tumor gene-1 (WT1). W8B2+ CRSCs can differentiate into the cardiovascular lineages and secrete various cytokines.
Overall design Comparative RNA sequencing was performed using W8B2+ cell from human atrial appendages (passage 2 from 3 different patients), c-Kit+ cell from human atrial appendages (passage 2 from 3 different patients) and W8B2+ cell from bone marrow (passage 3 from 2 different patients, from PromoCell, Heidelberg, Germany).
Contributor(s) Lim SY, Hewitt AW
Citation(s) 26184084
Submission date Oct 14, 2014
Last update date May 15, 2019
Contact name Alex Hewitt
Organization name University of Melbourne
Street address 32 Gisborne St
City East Melbourne
ZIP/Postal code 3002
Country Australia
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (8)
GSM1524869 ckit5
GSM1524870 ckit6
GSM1524871 ckit7
BioProject PRJNA263766
SRA SRP048889

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Supplementary file Size Download File type/resource
GSE62288_RAW.tar 56.3 Mb (http)(custom) TAR (of GTF)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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