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| Status |
Public on Sep 30, 2015 |
| Title |
Altered levels of circulating miRNAs are associated with Schistosoma japonicum infection in mice |
| Platform organisms |
Homo sapiens; Mus musculus; Rattus norvegicus; Human alphaherpesvirus 1; Human alphaherpesvirus 2; Cytomegalovirus; Human betaherpesvirus 5; Lymphocryptovirus; Rhadinovirus; JC polyomavirus; Human immunodeficiency virus 1; Murid gammaherpesvirus 4; Merkel cell polyomavirus; Betapolyomavirus hominis; Betapolyomavirus macacae |
| Sample organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
miRNA profiling of S. japonicum infected mouse plasma comparing control untreated mouse plasma.
Schistosomiasis, caused by dioecious flatworms in the genus Schistosoma, is torturing people predominantly in the developing countries. Knowledge on schistosome-host interaction and its parasitism may result in the development of novel strategies for schistosomiasis control. MicroRNAs (miRNAs) are involved in a wide range of biological processes including development, cell proliferation, metabolism ,signal transduction, et al. Circulating miRNAs are not only important biomarker associated the process of pathogenesis in many diseases and also are able to regulate target gene expression in recipient cells, just like hormones. In the present study, we investigated circulating miRNA profile associated with S. japonicum infection in mice using miRNA microarray.
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| Overall design |
Two-condition experiment, Control vs. S. japonicum infected. Biological replicates: 2 control, 2 transfected, One replicate per array.
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| Contributor(s) |
Zhu L, Cheng G, Dao J, Du X, Li H, Lu K |
| Citation(s) |
25885182 |
| |
| Submission date |
Nov 10, 2014 |
| Last update date |
Jan 15, 2020 |
| Contact name |
Lihui Zhu |
| E-mail(s) |
zlh309@163.com
|
| Organization name |
Shanghai Jiaotong University
|
| Department |
School of Agriculture and Biology
|
| Lab |
Shanghai Key Laboratory of Veterinary Biotechnology
|
| Street address |
800 Dongchuang Road
|
| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
200240 |
| Country |
China |
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| Platforms (1) |
| GPL16016 |
Exiqon miRCURY LNA microRNA array; 7th generation; batch 208500-2, 208510; lot 35004 - hsa, mmu & rno (miRBase 18.0) |
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| Samples (4)
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| GSM1541923 |
Control pooled mice plasma Replicate 1 (C1) |
| GSM1541924 |
Control pooled mice plasma Replicate 2 (C2) |
| GSM1541925 |
S. japonicum infected pooled mice plasma Replicate 1 (I1) |
| GSM1541926 |
S. japonicum infected pooled mice plasma Replicate 2 (I2) |
|
| Relations |
| BioProject |
PRJNA266801 |
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