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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Nov 02, 2015 |
| Title |
Global gene expression profiling of primary tumors and lung metastases using a mouse model of spontaneous metastatic mammary carcinoma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we explored the molecular basis of site-specific metastasis of breast cancer to the lungs in a clinically relevant model based on the JygMC(A) cell line. In this dataset, we include expression data from JygMC(A) primary mammary tumors, lung metastases, normal mammary glands and normal lung parenchyma.
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| Overall design |
In total, 28 samples were analyzed. We generated the following pairwise comparisons using Partek Genomic Suite 6.6 (PGS, Version 6.6, Partek Inc.): PT vs. NMG; PT vs. LM; LM vs. NL; LM vs. NMG. Genes with an FDR-adjusted p-value < 0.05 and a fold-change > 2 were selected.
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| Contributor(s) |
Pereira de Castro N, Salomon D, Merchant A, Abrams N |
| Citation(s) |
27077656, 26059540 |
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| Submission date |
Nov 25, 2014 |
| Last update date |
Oct 10, 2019 |
| Contact name |
David Salomon |
| E-mail(s) |
salomond@mail.nih.gov
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| Organization name |
NIH
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| Department |
NCI
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| Street address |
1050 Boyles Drive, Bldg. 560 Room 1246
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| City |
Frederick |
| State/province |
MD |
| ZIP/Postal code |
21701 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (28)
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| GSM1554197 |
mammary tumor metastases to lung, biological rep2 |
| GSM1554198 |
mammary tumor metastases to lung, biological rep3 |
| GSM1554199 |
mammary tumor metastases to lung, biological rep4 |
| GSM1554200 |
mammary tumor metastases to lung, biological rep5 |
| GSM1554201 |
mammary tumor metastases to lung, biological rep6 |
| GSM1554202 |
mammary tumor metastases to lung, biological rep7 |
| GSM1554203 |
mammary tumor metastases to lung, biological rep8 |
| GSM1554204 |
mammary tumor metastases to lung, biological rep9 |
| GSM1554205 |
mammary tumors, biological rep1 |
| GSM1554206 |
mammary tumors, biological rep2 |
| GSM1554207 |
mammary tumors, biological rep3 |
| GSM1554208 |
mammary tumors, biological rep4 |
| GSM1554209 |
mammary tumors, biological rep5 |
| GSM1554210 |
mammary tumors, biological rep6 |
| GSM1554211 |
mammary tumors, biological rep7 |
| GSM1554212 |
mammary tumors, biological rep8 |
| GSM1554213 |
mammary tumors, biological rep9 |
| GSM1554214 |
mammary tumors, biological rep10 |
| GSM1554215 |
mammary tumors, biological rep11 |
| GSM1554216 |
normal lung parenchyma, biological rep1 |
| GSM1554217 |
normal lung parenchyma, biological rep2 |
| GSM1554218 |
normal lung parenchyma, biological rep3 |
| GSM1554219 |
normal mammary gland, biological rep1 |
| GSM1554220 |
normal mammary gland, biological rep2 |
| GSM1554221 |
normal mammary gland, biological rep3 |
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| Relations |
| BioProject |
PRJNA268496 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE63627_RAW.tar |
92.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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