|
| Status |
Public on May 01, 2007 |
| Title |
Gene Profiling of Endometrium Reveals Progesterone Resistance and Candidate Genetic Loci in Women with Endometriosis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The transition of regularly cycling endometrium from the proliferative or Estrogen-dominant phase of the menstrual cycle to the Progesterone-dominant Early and Mid Secretory phases requires wide-spread changes in gene expression that shift the endometrium from a proliferative capacity to a differentiated 'decidual' phenotype in preparation for implantation. This process appears delayed in women with severe endometriosis, suggestive of a progesterone resistant endometrium in this disease.
Keywords: disease state analysis
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| |
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| Overall design |
Endometrial biopsies were obtained from women both with normal endometrial pathologies and no history of endometriosis and from women with laporoscopy proven moderate-severe stage endometriosis. Samples were collected from the Proliferative(PE), Early Secretory (ESE) and Midsecretory (MSE) phases. Samples were then processed for Total RNA isolation and Affymetrix chip hybridization.
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| |
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| Citation(s) |
17510236 |
| |
| Submission date |
Nov 24, 2006 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Linda Giudice |
| E-mail(s) |
giudice@obgyn.ucsf.edu
|
| Phone |
415-476-2039
|
| Organization name |
University of California, San Francisco
|
| Department |
OBGYN and RS
|
| Lab |
Giudice Lab
|
| Street address |
513 Parnassus Ave. HSE 1619
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94122 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (37)
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| Relations |
| BioProject |
PRJNA99579 |
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