GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE6364 Query DataSets for GSE6364
Status Public on May 01, 2007
Title Gene Profiling of Endometrium Reveals Progesterone Resistance and Candidate Genetic Loci in Women with Endometriosis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The transition of regularly cycling endometrium from the proliferative or Estrogen-dominant phase of the menstrual cycle to the Progesterone-dominant Early and Mid Secretory phases requires wide-spread changes in gene expression that shift the endometrium from a proliferative capacity to a differentiated 'decidual' phenotype in preparation for implantation. This process appears delayed in women with severe endometriosis, suggestive of a progesterone resistant endometrium in this disease.
Keywords: disease state analysis
Overall design Endometrial biopsies were obtained from women both with normal endometrial pathologies and no history of endometriosis and from women with laporoscopy proven moderate-severe stage endometriosis. Samples were collected from the Proliferative(PE), Early Secretory (ESE) and Midsecretory (MSE) phases. Samples were then processed for Total RNA isolation and Affymetrix chip hybridization.
Citation(s) 17510236
Submission date Nov 24, 2006
Last update date Mar 25, 2019
Contact name Linda Giudice
Phone 415-476-2039
Organization name University of California, San Francisco
Department OBGYN and RS
Lab Giudice Lab
Street address 513 Parnassus Ave. HSE 1619
City San Francisco
State/province CA
ZIP/Postal code 94122
Country USA
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (37)
GSM150190 PE_D_26A
GSM150191 PE_D_508
GSM150192 PE_D_587
BioProject PRJNA99579

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE6364_RAW.tar 182.1 Mb (http)(custom) TAR (of CEL)

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap