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Series GSE64832 Query DataSets for GSE64832
Status Public on Feb 01, 2016
Title UTX inhibition as selective epigenetic therapy against TAL1-driven T cell acute lymphoblastic leukemia
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Third-party reanalysis
Summary We performed ChIP-Seq in Jurkat T-ALL cells to identify UTX binding sites across the genome. We then compared UTX binding sites (this study) with TAL1 binding sites (Data from Palii, 2011 GSE25000), and found a high degree of overlap between TAL1 and UTX in Jurkat T-All cells. Indeed, over 80% of TAL1 binding sites overlap with UTX.
Overall design Using ChIP-Seq, we identified UTX binding across the genome in Jurkat T-ALL cells. We then compared the binding sites of UTX and TAL1 (Data from Palii, 2011 GSE25000).
Contributor(s) Benyoucef A, Palii CG, Chu A, Brand M
Citation(s) 26944678
Submission date Jan 09, 2015
Last update date May 15, 2019
Organization Ottawa Hospital Research Institute
Phone (613) 737-8899 -73255
Department Cellular and Molecular Medicine
Lab Ottawa Bioinformatics Core Facility
Street address 501 Smyth Rd.
City Ottawa
State/province ON
ZIP/Postal code K1H 8L6
Country Canada
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (2)
GSM1581343 Mock_ChIP
GSM1581344 UTX_ChIP
This SubSeries is part of SuperSeries:
GSE72300 T-cell ALL in response to TAL1-KD, UTX-KD, and GSKJ4 treatment
Reanalysis of GSM614005
Reanalysis of GSM614003
BioProject PRJNA272133
SRA SRP051971

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE64832_RAW.tar 1.2 Gb (http)(custom) TAR (of BED, BW)
GSE64832_Tal1_peaks.bed.gz 23.1 Kb (ftp)(http) BED
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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