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| Status |
Public on May 13, 2015 |
| Title |
Genes regulated in EML1 cells expressing the TEL-AML1 oncogene after 5 and 7 days of treatment with IL7 and FLT3 ligand. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The t(12;21) translocation is the most common genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) and gives rise to the TEL-AML1 fusion gene, which functions as a transcription factor.
TEL-AML1 expression in EML1 cells results in an impairment of differentiation along the B-lymphoid lineage.
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| Overall design |
We analyzed gene expression profiles of EML1 cells after expression of TEL-AML1
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| Contributor(s) |
Alcalay M |
| Citation(s) |
25893288 |
| Submission date |
Jan 13, 2015 |
| Last update date |
Apr 18, 2017 |
| Contact name |
Myriam Alcalay |
| E-mail(s) |
myriam.alcalay@ieo.eu
|
| Organization name |
European Institute of Oncology
|
| Department |
Experimental Oncology
|
| Lab |
Functional Genomics
|
| Street address |
Via Adamello 16
|
| City |
Milan |
| ZIP/Postal code |
20139 |
| Country |
Italy |
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| Platforms (1) |
| GPL11533 |
[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version] |
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| Samples (12)
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| GSM1583299 |
EML1 infected with the empty pWPI lentiviral vector - rep 1 |
| GSM1583300 |
EML1 infected with the empty pWPI lentiviral vector - rep 2 |
| GSM1583301 |
EML1 infected with the empty pWPI lentiviral vector treated with IL7 and FLT3L for 5 days- rep 1 |
| GSM1583302 |
EML1 infected with the empty pWPI lentiviral vector treated with IL7 and FLT3L for 5 days- rep 2 |
| GSM1583303 |
EML1 infected with the empty pWPI lentiviral vector treated with IL7 and FLT3L for 7 days- rep 1 |
| GSM1583304 |
EML1 infected with the empty pWPI lentiviral vector treated with IL7 and FLT3L for 7 days- rep 2 |
| GSM1583305 |
EML1 infected with the TEL-AML1 ccs cloned into thepWPI lentiviral vector - rep 1 |
| GSM1583306 |
EML1 infected with the TEL-AML1 ccs cloned into thepWPI lentiviral vector - rep 2 |
| GSM1583307 |
EML1 infected with the TEL-AML1 ccs cloned into thepWPI lentiviral vector treated with IL7 and FLT3L for 5 days- rep 1 |
| GSM1583308 |
EML1 infected with the TEL-AML1 ccs cloned into thepWPI lentiviral vector treated with IL7 and FLT3L for 5 days- rep 2 |
| GSM1583309 |
EML1 infected with the TEL-AML1 ccs cloned into thepWPI lentiviral vector treated with IL7 and FLT3L for 7 days- rep 1 |
| GSM1583310 |
EML1 infected with the TEL-AML1 ccs cloned into thepWPI lentiviral vector treated with IL7 and FLT3L for 7 days- rep 2 |
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| Relations |
| BioProject |
PRJNA272512 |
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