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Series GSE65021 Query DataSets for GSE65021
Status Public on Aug 01, 2016
Title Gene expression profile in relapsed or metastatic HNSCC patients treated with cetuximab and platinum therapy
Organism Homo sapiens
Experiment type Expression profiling by array
Summary First line chemotherapy with platinum and cetuximab is usually offered to RM-HNSCC pts. In the Extreme trial a median progression free survival (PFS) time of 5.6 months was reported. However, a small fraction of pts achieves a prolonged PFS (> than 12 months). Till now, no recognized predictive biological factor has been identified.
Overall design A group of 14 cases treated with a first line platinum and cetuximab with a PFS exceeding 12 months (long PFS) and a group of 26 pts with a PFS less than 5.6 months (short PFS) were selected. The 2 groups were well balanced in regard to recognized prognostic factors (performance status, weight loss, prior radiotherapy, tumor grade, site of primary tumor, residual disease at primary tumor site). Tumor specimens of the recurrence or, if not available, of the primary tumor were collected. In order to identify molecular profiles deregulated between the 2 groups, a gene expression microarray analysis was performed using the Whole-Genome DASL assay and HumanHT-12_v4 BeadArray chips (lllumina).

Gender: male=0; female=1.
Age: years at diagnosis
Site of primary: oral cavity=0; oropharynx=1; hypopharynx=2; larynx=3.
Stage of T at first diagnosis according to AJCC 8th edition
Grading according to WHO: well differentiated=1; moderately differentiated=2; scarcely differentiated=3.
Radiotherapy (RT) prior to recurrence: No=0; Yes=1.
Progression Free Survival (PFS): Long (>12 months); Short(<5 months).
Contributor(s) De Cecco L
Citation(s) 26920888
Submission date Jan 15, 2015
Last update date Dec 22, 2017
Contact name Loris De Cecco
Organization name IRCSS Istituto Nazionale Tumori
Street address via Venezian 1
City Milan
ZIP/Postal code 20133
Country Italy
Platforms (1)
GPL14951 Illumina HumanHT-12 WG-DASL V4.0 R2 expression beadchip
Samples (40)
GSM1585940 7964427070_A: AY45
GSM1585941 7964427070_B: BA81
GSM1585942 7964427070_C: AY47
BioProject PRJNA272724

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE65021_non-normalized.txt.gz 6.2 Mb (ftp)(http) TXT
Processed data included within Sample table

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