We show that WA09 human embryonic stem cells (hESC) cultured in minimal media and treated with BMP4 for 4 days differentiate towards a cytotrophoblast (CTB)-like state.
Overall design
We have compared gene expression profiling of WA09 hESC cultured in minimal media and treated with BMP4 for 4 days to a panel of placental tissues (Amnion, and Stroma), primary cells (first and third trimester CTB) and placenta-derived cell lines (choriocarcinoma-derived BEWO and JEG3, and immoratalised extravillous trophoblast (EVT) cell line HTR8).
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