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Series GSE65774 Query DataSets for GSE65774
Status Public on Feb 15, 2016
Title Transcriptome profiling in knock-in mouse models of Huntington's disease [Striatum_mRNA]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for this disease is an abnormally expanded and unstable CAG repeat within the coding region of the gene encoding huntingtin (Htt). Knock-in mouse models of HD with human exon 1 containing expanded CAG repeats inserted in the murine huntingtin gene (Hdh) provide a genetic reconstruction of the human causative mutation within the mouse model. The goal of this study is RNA expression profiling by RNA sequencing (RNA-seq) in 2, 6, and 10 month old knock-in mice with CAG lengths of 20, 80, 92, 111, 140, 175 along with littermate control wild-type animals
 
Overall design mRNA expression profiles were obtained via RNA-seq analysis performed on tissue samples from the striatum of 2, 6, and 10 month old knock-in mice with CAG lengths of 20, 80, 92, 111, 140, 175 along with littermate control wild-type animals.
 
Contributor(s) Aaronson J, Rosinski J
Citation(s) 26900923
Submission date Feb 09, 2015
Last update date May 15, 2019
Contact name Jeff Aaronson
E-mail(s) jeff.aaronson@chdifoundation.org
Phone (609) 945-9616
Organization name CHDI
Department Discovery & Systems Biology
Street address 155 Village Boulevard, Suite 200
City Princeton
State/province New Jersey
ZIP/Postal code 08540
Country USA
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (208)
GSM1605718 HET (Q111) 2 month Female striatum mRNA rep1
GSM1605719 HET (Q111) 2 month Female striatum mRNA rep2
GSM1605720 HET (Q111) 2 month Female striatum mRNA rep3
This SubSeries is part of SuperSeries:
GSE65776 Transcriptome profiling in knock-in mouse models of Huntington's disease [striatum; cortex; liver; tissue survey]
Relations
BioProject PRJNA274985
SRA SRP053398

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Supplementary file Size Download File type/resource
GSE65774_Striatum_mRNA_FPKM_processedData.txt.gz 13.1 Mb (ftp)(http) TXT
GSE65774_Striatum_mRNA_counts_processedData.txt.gz 10.5 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record
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