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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Apr 22, 2016 |
| Title |
Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We analyzed gene expression in CD4+ cells sorted from naïve or D30 Mycobacterium tuberculosis-infected mice and incubated in vitro in the presence or absence of Schistosoma egg antigen. We found genes associated with Th1 function, T cell signaling, T cell costimulation and T cell activation were downregulated in SEA-treated cells, while expression of Th2 cytokines was below the threshold for detection.
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| Overall design |
RNAseq results for 3 replicates for naïve or CD4+ T cells from M.tuberculosis-infected mice treated with or without Schistosoma egg antigen in vitro.
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| Contributor(s) |
Monin L, Griffiths KL, Lam WY, Gopal R, Kang DD, Rajamanickam A, Cruz-Lagunas A, Zúñiga J, Babu S, Kolls JK, Mitreva M, Rosa BA, Ramos-Payan R, Murray PJ, Rangel-Moreno J, Pearce EJ, Khader SA |
| Citation(s) |
26571397, 37012543 |
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| Submission date |
Mar 05, 2015 |
| Last update date |
Jun 12, 2024 |
| Contact name |
Shabaana Khader |
| E-mail(s) |
khader@wustl.edu
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| Organization name |
Washington University in St.Louis
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| Department |
Department of Molecular Microbiology
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| Street address |
660 South Euclid Avenue
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| City |
St.Louis |
| State/province |
MO |
| ZIP/Postal code |
63110 |
| Country |
USA |
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| Platforms (1) |
| GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA277356 |
| SRA |
SRP055876 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE66578_SEA.txt.gz |
237.0 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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