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Series GSE68571 Query DataSets for GSE68571
Status Public on May 06, 2015
Title caArray_beer-00153: Gene-expression profiles predict survival of patients with lung adenocarcinoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Histopathology is insufficient to predict disease progression and clinical outcome in lung adenocarcinoma. Here we show that gene-expression profiles based on microarray analysis can be used to predict patient survival in early-stage lung adenocarcinomas. Genes most related to survival were identified with univariate Cox analysis. Using either two equivalent but independent training and testing sets, or 'leave-one-out' cross-validation analysis with all tumors, a risk index based on the top 50 genes identified low-risk and high-risk stage I lung adenocarcinomas, which differed significantly with respect to survival. This risk index was then validated using an independent sample of lung adenocarcinomas that predicted high- and low-risk groups. This index included genes not previously associated with survival. The identification of a set of genes that predict survival in early-stage lung adenocarcinoma allows delineation of a high-risk group that may benefit from adjuvant therapy.
 
Overall design beer-00153
Assay Type: Gene Expression
Provider: Affymetrix
Array Designs: Hu6800
Organism: Homo sapiens (ncbitax)
Disease States: lung cancer, normal
 
Citation(s) 12118244
Submission date May 05, 2015
Last update date Jul 08, 2016
Contact name Mervi Heiskanen
E-mail(s) mervi.heiskanen@nih.gov
Phone 2402765175
Organization name NCI
Department CBIIT
Street address 9609 Medical Center Drive, 1W378
City Rockville
State/province MD
ZIP/Postal code 20850
Country USA
 
Platforms (1)
GPL80 [Hu6800] Affymetrix Human Full Length HuGeneFL Array
Samples (96)
GSM1675665 beer-00153: AD10
GSM1675666 beer-00153: AD2
GSM1675667 beer-00153: AD3
Relations
BioProject PRJNA283120

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE68571_RAW.tar 214.5 Mb (http)(custom) TAR (of CEL, TXT)
GSE68571_caArray_beer-00153.tar.gz 795.5 Kb (ftp)(http) TAR
Processed data included within Sample table
Processed data provided as supplementary file

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