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| Status |
Public on Jun 27, 2015 |
| Title |
Gene expression data of C57BL/6, Il1a-knockout and Il1b-knockout mice at 24 hours after spinal cord injury |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We have previously shown that Il1a-knockout (KO) mice exhibit rapid (at day 1) and persistent improvements in locomotion associated with reduced lesion volume compared with Il1b-KO mice and C57BL/6 controls after traumatic spinal cord injury (SCI). To investigate the mechanism by which Il1a mediates its detrimental effect, we analyzed the transcriptome of the injured spinal cord of Il1a-KO, Il1b-KO and C57BL/6 mice at 24 hours after SCI using GeneChip microarrays.
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| Overall design |
Il1a-KO, Il1b-KO and C57BL/6 mice were subjected to a 50-kdyn SCI and a 6-mm spinal cord segment centered over the site of contusion extracted for RNA isolation and microarray analysis.
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| Contributor(s) |
Lacroix S |
| Citation(s) |
26224856 |
| Submission date |
Jun 26, 2015 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Steve Lacroix |
| E-mail(s) |
Steve.Lacroix@crchul.ulaval.ca
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| Organization name |
Centre de recherche du Centre hospitalier universitaire (CHU) de Québec - CHUL
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| Department |
Médecine moléculaire
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| Street address |
2705, boul. Laurier
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| City |
Québec |
| State/province |
Québec |
| ZIP/Postal code |
G1V 4G2 |
| Country |
Canada |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA288278 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE70302_RAW.tar |
52.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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