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Series GSE70477 Query DataSets for GSE70477
Status Public on Jan 01, 2017
Title Differential transcriptional networks regulated by high sugar consumption in normal and high-fat-fed mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary High sugar consumption, as well as high-fat diet, is a known cause of obesity and metabolic syndrome. However, the synergistic effect of high-sugar and high-fat consumption rarely has been evaluated, especially in terms of transcriptional regulation. Therefore, we focused on the effect of high sugar consumption on hepatic transcriptional networks in normal and high fat-fed mice. C57BL/6J mice were divided into four groups and were provided either 23%(w/v) sugar solution or plain water with either high-fat or normal-fat diet for 10 weeks. As a result, high sugar consumption significantly altered lipid metabolism-related genes in normal fat-fed mice; however, in high fat-fed mice, high sugar consumption altered inflammation-responsive genes rather than lipid metabolism. After all, these modulations eventually increased lipid accumulation in the liver and caused systemic metabolic disturbances. These observations for the first time suggested that high sugar consumption along with high-fat diet could lead to the development of severe metabolic syndrome via altering hepatic transcriptional networks.
 
Overall design Total RNA was obtained from liver tissues in C57BL/6J mice supplied either plain water or 23% (w/v) sugar drink with either normal- or high-fat diet for 10 weeks.
 
Contributor(s) Lee J, Shin D
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Submission date Jul 02, 2015
Last update date Jan 16, 2019
Contact name Jooyoung Lee
Organization name Seoul National University
Street address 1 Gwanak-ro, Gwanak-gu
City Seoul
ZIP/Postal code 151-742
Country South Korea
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (24)
GSM1782629 Control rep1
GSM1782630 Control rep2
GSM1782631 Control rep3
Relations
BioProject PRJNA288795

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE70477_RAW.tar 15.8 Mb (http)(custom) TAR
GSE70477_non-normalized.txt.gz 6.9 Mb (ftp)(http) TXT
Processed data included within Sample table

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