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| Status |
Public on May 16, 2016 |
| Title |
Gene expression changes in the retina following human neural progenitor cell injection into a rodent model for retinal degeneration |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The goal of this study is to compare gene expression changes in retinal degenerate Royal College of Surgeons (RCS) rats following an injection of human neural progenitor cells (hNPCs) using RNA-seq, as compared to RCS rats receiving a sham surgery and wild-type Long Evans rats. These changes may lead to understanding of the therapeutic potential of hNPCs in inducing photoreceptor survival and visual function preservation.
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| |
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| Overall design |
RNA-seq from wild-type Long Evans rats, retinal degenerate Royal College of Surgeons (RCS) rats, and RCS rats following transplantation of human neural progenitor cells (hNPCs)
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| |
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| Contributor(s) |
Jones MK, Saghizadeh M, Lu B, Svendsen CN, Wang S |
| Citation(s) |
27217715 |
| |
| Submission date |
Jul 07, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Melissa Kaye Jones |
| Organization name |
Cedars-Sinai Medical Center
|
| Department |
Biomedical Sciences
|
| Lab |
Shaomei Wang
|
| Street address |
8700 Beverly Blvd.
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90048 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL20670 |
Ion Torrent PGM (Rattus norvegicus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA289237 |
| SRA |
SRP060514 |
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