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Series GSE71128 Query DataSets for GSE71128
Status Public on Jul 17, 2016
Title Mapping the Chromatin State Dynamics in Myoblasts
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The chromatin state in developing body parts provides a zip code to cellular populations that direct their cell fates. We used antibodies for H3K4me3, H3K27me3 and Pol2, to identify the chromatin state signature of the Pitx2-null mouse forelimb during mid-gestation, at embryonic day 12. The families of genes marked included those related to transcription, transcriptional regulation, and embryonic organ development. Transcription factors specific for muscle development were characterized by bivalent chromatin, as E12 is a transition time point from embryonic to fetal myogenesis. The identified chromatin state of muscle specific genes was in strong correlation with their observed expression profile.
Overall design Examination of the histone marks H3K4me3, H3k27me3, and Pol2 in whole E12.5 forelimb tissues from Pitx2 null mice using the Illumina HiSeq 2000
Contributor(s) Kioussi C, Eng D, Singh A
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Submission date Jul 20, 2015
Last update date May 15, 2019
Contact name Chrissa Kioussi
Organization name Oregon State University
Department College of Pharmacy
Lab Chrissa Kioussi
Street address 1601 SW Jefferson Way
City Corvallis
State/province Oregon
ZIP/Postal code 97331
Country USA
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (4)
GSM1827869 Pitx2-null_Input
GSM1827875 Pitx2-null_H3K4me3
GSM1827877 Pitx2-null_H3K27me3
BioProject PRJNA290430
SRA SRP061353

Download family Format
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Supplementary file Size Download File type/resource
GSE71128_RAW.tar 1.1 Gb (http)(custom) TAR (of BB, BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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