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| Status |
Public on Jul 23, 2015 |
| Title |
Expression data from Jurkat cells treated with SB225002 for 6h and 9h. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
In our efforts to evaluate the function of the IL-8 receptor CXCR2 in Acute Lymphoblastic Leukemia (ALL) cells, we made use of SB225002 (N-(2-hydroxy-4-nitrophenyl)-N’-(2-bromophenyl)urea), a drug initially described as a CXCR2 antagonist. Although the CXCR2 receptor was found to be non-functional in ALL, B- and T-ALL cell lines were sensitive to SB225002.
We used microarray analysis to identify a transcriptional profile of genes that mediate SB225002's effects in acute lymphoblastic leukemia cells.
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| Overall design |
Jurkat cells were treated for 6h or 9h with SB225002 [12.5 uM] or 0.1% DMSO (vehicle control).
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| Contributor(s) |
Ferreira de Vasconcellos J, Libermann TA, Zerbini L, Yunes J |
| Citation(s) |
26302043 |
| |
| Submission date |
Jul 22, 2015 |
| Last update date |
Jan 17, 2017 |
| Contact name |
Jaira Ferreira de Vasconcellos |
| Organization name |
Centro Infantil Boldrini
|
| Lab |
Molecular Biology Laboratory
|
| Street address |
Rua Dr. Gabriel Porto, 1270.
|
| City |
Campinas |
| State/province |
Sao Paulo |
| ZIP/Postal code |
13083-210 |
| Country |
Brazil |
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| Platforms (2) |
| GPL3921 |
[HT_HG-U133A] Affymetrix HT Human Genome U133A Array |
| GPL9197 |
[HT_HG-U133B] Affymetrix HT Human Genome U133B Array |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA290610 |
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