NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE71429 Query DataSets for GSE71429
Status Public on Feb 01, 2016
Title Infinium 850k Beadchip analysis of control human brain for copy number mosaicism
Organism Homo sapiens
Experiment type SNP genotyping by SNP array
Summary Copy number mosaicism in the human brain has been reported recently by several authors. This experiment was performed to further investigate our preliminary data of apparent widespread deletions in brain DNA, detected in a custom Agilent aCGH designed for Parkinson's disease (PD) genes in both patients and controls, and supported by droplet digital PCR.
To avoid any effect of diseased tissue, we used only controls here. All DNA was freshly extracted. A validated SNP array was chosen to ensure that our results were not due to artefacts specific to the aCGH design used, with SNP array giving the additional advantage of B allele frequency estimation.
 
Overall design Seven DNA samples were analysed, from four healthy individuals whose brain had been fresh frozen. The cerebellum and frontal cortex were analysed from three, and the cerebellum only for one.
 
Contributor(s) Proukakis C
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jul 28, 2015
Last update date Feb 01, 2016
Contact name Christos Proukakis
E-mail(s) c.proukakis@ucl.ac.uk
Organization name UCL Institute of Neurology
Department Clinical Neuroscience
Street address Rowland Hill Street
City London
ZIP/Postal code NW3 2PF
Country United Kingdom
 
Platforms (1)
GPL19718 IIllumina Infinium human CytoSNP-850K BeadChip
Samples (7)
GSM1834110 C1 cerebellum
GSM1834111 C2 cerebellum
GSM1834112 C3 cerebellum
This SubSeries is part of SuperSeries:
GSE71470 Modifying DNA extraction protocol alters human brain copy number estimation
Relations
BioProject PRJNA291175

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71429_RAW.tar 295.7 Mb (http)(custom) TAR (of IDAT, TXT)
Processed data provided as supplementary file

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap