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Series GSE71596 Query DataSets for GSE71596
Status Public on Sep 15, 2015
Title Epigenetic profiling of Juvenile Idiopathic Arthritits (JIA) patients
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary With H3K27ac chromatin immunoprecipitation we identified a disease-specific, inflammation-associated, (super-)enhancer signature in JIA patient synovial fluid-derived CD4+ memory/effector T cells. This signature consists of unique pathogenesis-associated epigenetic changes which extend beyond general T cell activation-induced alterations, indicating that disease-specific (super-)enhancers contribute to JIA pathogenesis. In addition, our analysis shows that there is a profound enrichment of JIA-related SNPs in (super-)enhancers in JIA patients compared to controls, illustrating the importance of these non-coding regions for disease pathogenesis.
Overall design H3K27ac ChIP-sequencing of CD4+ memory/effector T cells derived from peripheral blood (PB) from healthy controls (HC) and PB or synovial fluid (SF) from JIA patients.
Contributor(s) . van Loosdregt J, Peeters JG, Vervoort SJ
Citation(s) 26387944
Submission date Jul 31, 2015
Last update date May 15, 2019
Contact name Janneke Peeters
Organization name UMC Utrecht
Street address Heidelberglaan 100
City Utrecht
ZIP/Postal code 3584CX
Country Netherlands
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (15)
GSM1841082 HC_A_Run1
GSM1841083 HC_A_act_Run1
GSM1841084 HC_B_Run2
This SubSeries is part of SuperSeries:
GSE71597 Epigenetic profiling and RNA-sequencing of Juvenile Idiopathic Arthritits (JIA) patients
BioProject PRJNA291598
SRA SRP061882

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71596_RAW.tar 2.2 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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