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Series GSE7210 Query DataSets for GSE7210
Status Public on May 01, 2008
Title Relapse versus diagnostic acute myeloid leukaemia samples analysed using Affymetrix 10K SNP array
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary Relapse is the commonest cause of death in acute myeloid leukaemia (AML), but the mechanisms leading to relapse are unclear. Recently, acquisition of segmental uniparental disomy (UPD) by mitotic recombination (MR) has been reported in 15-20% of AML samples at diagnosis using whole genome single nucleotide polymorphism (SNP) arrays. These cytogenetically invisible abnormalities are associated with homozygous mutations in several types of malignancy. Clonal evolution of heterozygous to homozygous mutations by MR could provide a mechanism for relapse.
Keywords: DNA copy number, loss of heterozygosity
 
Overall design DNA from 27 pairs of diagnostic and relapsed AML samples were analysed using Affymetrix 10K SNP arrays. The genotype data of relapsed AML were compared with the data from the corresponding presentation AML.
 
Contributor(s) Raghavan M, Smith L, Lillington DM, Chaplin T, Kakkas I, Molloy G, Chelala C, Fitzgibbon J, Lister TA, Young BD, Cavenagh JD, Cazier J
Citation(s) 18490517
Submission date Mar 06, 2007
Last update date Jun 24, 2013
Contact name Manoj Raghavan
E-mail(s) manoj.raghavan@cancer.org.uk
Phone +44 20 7882 6141
Fax +44 20 7882 6004
Organization name Barts and the London, Queen Mary's School of Medicine and Dentistry
Department Centre for Medical Oncology, Institute of Cancer
Lab Medical Oncology Unit
Street address Charterhouse Square
City London
ZIP/Postal code EC1M 6BQ
Country United Kingdom
 
Platforms (2)
GPL1266 [Mapping10K_Xba131] Affymetrix Human Mapping 10K SNP Array
GPL2641 [Mapping10K_Xba142] Affymetrix Human Mapping 10K 2.0 Array
Samples (54)
GSM173388 AML Patient 1 Diagnosis
GSM173389 AML patient 2 Diagnosis
GSM173390 AML patient 3 Diagnosis
Relations
BioProject PRJNA98303

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Supplementary file Size Download File type/resource
GSE7210_RAW.tar 111.7 Mb (http)(custom) TAR (of CEL, XML)

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