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Series GSE72494 Query DataSets for GSE72494
Status Public on Jan 01, 2017
Title Effector regulatory T cell differentiation and immune homeostasis depend on the transcription factor Myb
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary FoxP3-expressing regulatory T (Treg) cells are essential to maintain immune homeostasis. Activated Treg cells undergo further differentiation into an effector state that highly express genes critical for Treg cell function. Here we demonstrate that mice lacking the transcription factor Myb in Treg cells succumb to a multi-organ inflammatory disease. Myb was specifically expressed in, and required for the differentiation of, thymus-derived effector Treg cells. The combination of transcriptome and DNA binding analyses revealed that Myb directly regulates a large proportion of the effector Treg cell specific gene expression in mouse and human cells. This study identifies a critical role for Myb in the gene regulatory network controlling effector Treg cell differentiation and function.
Overall design Transcriptional profiling of naïve, activated and effector Treg cell populations using RNA sequencing
Contributor(s) Shi W, Dias S, Smyth GK, Nutt SL
Citation(s) 28099866
Submission date Aug 28, 2015
Last update date May 15, 2019
Contact name Wei Shi
Organization name Olivia Newton-John Cancer Research Institute
Street address 145 Studley Road
City Heidelberg
State/province Victoria
ZIP/Postal code 3084
Country Australia
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (10)
GSM1863253 Myb knockout activated Tregs rep1
GSM1863254 Myb knockout activated Tregs rep2
GSM1863255 Myb knockout naive Tregs rep1
BioProject PRJNA294161
SRA SRP062948

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Supplementary file Size Download File type/resource
GSE72494_RAW.tar 1.8 Mb (http)(custom) TAR (of TXT)
GSE72494_Supplementary_raw_counts.txt.gz 430.5 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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