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| Status |
Public on Jun 12, 2017 |
| Title |
Molecular signatures associated with cognitive deficits in schizophrenia: a study of biopsied olfactory neural epithelium |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Cognitive deficit is a key feature of schizophrenia (SZ) and determines functional outcome. Nonetheless, molecular signatures underlying the deficit in neuronal tissues are not well understood.
We performed microarray analysis of olfactory epithelium (OE) tissues from SZ and control subjects with their neuropsychological assessment data. Furthermore, we examined gene expression profiles of lymphoblasts for the molecular signatures identified in the OE tissues .
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| Overall design |
We used the following 3 sample sets for the microarray analysis: A) microdisected samples enriched for neuronal layers of OE tissues, B) paired lymphoblast samples , and C) non-paired lymphoblast samples. The first and second sampe sets (A and B) were derived from the same participants, while the third sample set (C) was from participants from another independent cohort.
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| Contributor(s) |
Horiuchi Y, Kondo MA, Okada K, Takayanagi Y, Tanaka T, Ho T, Varvaris M, Tajinda K, Hiyama H, Ni K, Colantuoni C, Schretlen D, Cascella NG, Pevsner J, Ishizuka K, Sawa A |
| Citation(s) |
27727244 |
| |
| Submission date |
Sep 17, 2015 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Akira Sawa |
| E-mail(s) |
asawa1@jhmi.edu
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| Phone |
410-955-4726
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| Organization name |
Johns Hopkins University School of Medicine
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| Department |
Psychiatry and Behavioral Sciences
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| Street address |
600 North Wolfe St.
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| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21287 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (115)
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| Relations |
| BioProject |
PRJNA296082 |
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