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Series GSE73503 Query DataSets for GSE73503
Status Public on Nov 03, 2015
Title Transcriptome profiling in knock-in mouse models of Huntington's disease [Hippocampus_mRNA]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for this disease is an abnormally expanded and unstable CAG repeat within the coding region of the gene encoding huntingtin (Htt). Knock-in mouse models of HD with human exon 1 containing expanded CAG repeats inserted in the murine huntingtin gene (Hdh) provide a genetic reconstruction of the human causative mutation within the mouse model. The goal of this study is RNA expression profiling by RNA sequencing (RNA-seq) in 2, 6, and 10 month old knock-in mice with CAG lengths of 20, 80, 92, 111, 140, 175 along with littermate control wild-type animals
 
Overall design mRNA expression profiles were obtained via RNA-seq analysis performed on tissue samples from the hippocampus of 2, 6, and 10 month old knock-in mice with CAG lengths of 20, 80, 92, 111, 140, 175 along with littermate control wild-type animals.
 
Contributor(s) Aaronson J, Rosinski J
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Submission date Sep 28, 2015
Last update date May 15, 2019
Contact name Jeff Aaronson
E-mail(s) jeff.aaronson@chdifoundation.org
Phone (609) 945-9616
Organization name CHDI
Department Discovery & Systems Biology
Street address 155 Village Boulevard, Suite 200
City Princeton
State/province New Jersey
ZIP/Postal code 08540
Country USA
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (168)
GSM1896279 Het (Q111) 10 month Female Hippocampus mRNA rep1
GSM1896280 Het (Q111) 10 month Female Hippocampus mRNA rep2
GSM1896281 Het (Q111) 10 month Female Hippocampus mRNA rep3
This SubSeries is part of SuperSeries:
GSE73508 Transcriptome profiling in knock-in mouse models of Huntington's disease [cerebellum; hippocampus]
Relations
BioProject PRJNA297190
SRA SRP064245

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE73503_mRNA_2__6__and_10_month_hippocampus_FPKM.xlsx 39.6 Mb (ftp)(http) XLSX
GSE73503_mRNA_2__6__and_10_month_hippocampus_counts.xlsx 33.3 Mb (ftp)(http) XLSX
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Processed data are available on Series record
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