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Series GSE73507 Query DataSets for GSE73507
Status Public on Nov 03, 2015
Title Transcriptome profiling in knock-in mouse models of Huntington's disease [Hippocampus_miRNA]
Organism Mus musculus
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for this disease is an abnormally expanded and unstable CAG repeat within the coding region of the gene encoding huntingtin (Htt). Knock-in mouse models of HD with human exon 1 containing expanded CAG repeats inserted in the murine huntingtin gene (Hdh) provide a genetic reconstruction of the human causative mutation within the mouse model. The goal of this study is RNA expression profiling by RNA sequencing (RNA-seq) in 2, 6, and 10 month old knock-in mice with CAG lengths of 20, 80, 92, 111, 140, 175 along with littermate control wild-type animals.
 
Overall design miRNA expression profiles were obtained via RNA-seq analysis performed on tissue samples from the hippocampus of 2, 6, and 10 month old knock-in mice with CAG lengths of 20, 80, 92, 111, 140, 175 along with littermate control wild-type animals.
 
Contributor(s) Aaronson J, Rosinski J
Citation(s) 29324753
Submission date Sep 28, 2015
Last update date May 15, 2019
Contact name Jeff Aaronson
E-mail(s) jeff.aaronson@chdifoundation.org
Phone (609) 945-9616
Organization name CHDI
Department Discovery & Systems Biology
Street address 155 Village Boulevard, Suite 200
City Princeton
State/province New Jersey
ZIP/Postal code 08540
Country USA
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (168)
GSM1896644 Het (Q111) 10 months Female Hippocampus miRNA rep1
GSM1896645 Het (Q111) 10 months Female Hippocampus miRNA rep2
GSM1896646 Het (Q111) 10 months Female Hippocampus miRNA rep3
This SubSeries is part of SuperSeries:
GSE73508 Transcriptome profiling in knock-in mouse models of Huntington's disease [cerebellum; hippocampus]
Relations
BioProject PRJNA297189
SRA SRP064247

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Supplementary file Size Download File type/resource
GSE73507_miRNA_2_6_and_10_month_hippocampus_RPKM.xlsx 2.0 Mb (ftp)(http) XLSX
GSE73507_miRNA_2_6_and_10_month_hippocampus_counts.xlsx 1.3 Mb (ftp)(http) XLSX
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