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Series GSE73783 Query DataSets for GSE73783
Status Public on Apr 04, 2016
Title Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations [ChIP-seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type specific gene expression profiles. Here, we perform HiC chromosome conformation, ChIP-seq and RNA-seq to investigate how the three-dimensional organization of the cancer genome is disrupted in the context of epigenetic remodelling and atypical gene expression programs.
 
Overall design Hi-C, ChIP-seq and RNA-seq were conducted in three human prostate cell lines: normal prostate epithelial cells (PrEC) and prostate cancer cells (PC3 and LNCaP).
 
Contributor(s) Taberlay P, Achinger-Kawecka J
Citation(s) 27053337
Submission date Oct 06, 2015
Last update date May 15, 2019
Contact name Joanna Achinger-Kawecka
E-mail(s) j.achinger@garvan.org.au
Organization name Garvan Institute of Medical Research
Lab Epigenetics Research Laboratory
Street address 384 Victoria Street
City Darlinghurst
State/province NSW
ZIP/Postal code 2010
Country Australia
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (3)
GSM1902615 LNCaP_H3K27ac_ChIP-seq
GSM1902616 LNCaP_H3K4me1_ChIPSeq
GSM1902617 LNCaP_Input
This SubSeries is part of SuperSeries:
GSE73785 Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations
Relations
BioProject PRJNA297886
SRA SRP064525

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE73783_RAW.tar 2.2 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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