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Series GSE74632 Query DataSets for GSE74632
Status Public on Nov 04, 2015
Title Bortezomib resistance in CCRF-CEM cell line [miRNA]
Organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Bortezomib is a proteasome inhibitor used in severel different hematological malignancies. Resistance to this drug is still poorly understood. In order get more insight in the resistance mechanism, we developed several bortezomib resistant subclones of the CCRF-CEM T-ALL cell line. On these subclones comparative Genome hybridization (arrayCGH) for DNA copy number analysis gene expression and micro-RNA expression arrays were performed.
Overall design We performed micro-RNA on two different bortezomib resistant subclones of the CCRF-CEM cell line. The resistant subclones were compared to the parental CCRF-CEM wildtype cell line.
Contributor(s) Franke NE, Kaspers GL, Assaraf YG, van Meerloo J, Niewerth D, Kessler FL, Poddighe PJ, Smeets S, Ylstra B, Bi C, Chng WJ, Horton TM, Menezes RX, Musters RJ, Zweegman S, Jansen G, Cloos J
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Submission date Nov 03, 2015
Last update date Nov 05, 2015
Contact name Daoud Sie
Phone +31 20 4442428
Organization name Vrije Universiteit Medical Center
Department Pathology
Lab Microarray Core Facility
Street address De Boelelaan 1117
City Amsterdam
ZIP/Postal code 1081 HV
Country Netherlands
Platforms (1)
GPL8227 Agilent-019118 Human miRNA Microarray 2.0 G4470B (miRNA ID version)
Samples (4)
GSM1924719 CEM_WT Replicate 1
GSM1924720 CEM_WT Replicate 2
GSM1924721 CEM_BTZ100
This SubSeries is part of SuperSeries:
GSE74635 Bortezomib resistance in CCRF-CEM cell line
BioProject PRJNA301041

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE74632_RAW.tar 3.3 Mb (http)(custom) TAR (of TXT)
GSE74632_miRNA_fold_change.txt.gz 647 b (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

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