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Series GSE7485 Query DataSets for GSE7485
Status Public on Aug 01, 2007
Title A transcriptome analysis of the Vibrio fischeri LuxR-LuxI regulon
Organism Aliivibrio fischeri
Experiment type Expression profiling by array
Summary Acyl-homoserine lactone (acyl-HSL) quorum sensing was first discovered in Vibrio fischeri where it serves as a key control element of the seven-gene luminescence (lux) operon. Since this initial discovery, other bacteria have been shown to control hundreds of genes by acyl-HSL quorum sensing. Until recently, it has been difficult to examine the global nature of quorum sensing in V. fischeri. However, the complete genome sequence of V. fischeri is now available and this has enabled us to use transcriptomics to identify quorum-sensing regulated genes and to study the quorum-controlled regulon of this bacterium. In this study, we used DNA microarray technology to identify over two-dozen V. fischeri genes regulated by the quorum sensing signal N-3-oxohexanoyl-L-homoserine lactone (3OC6-HSL).
Keywords: Comparison of transcriptome profiles
 
Overall design Transcriptome profiles of Vibrio fischeri ES114 grown in the absence or presence of exogenously added 3OC6-HSL were compared.
 
Contributor(s) Antunes LM, Schaefer AL, Greenberg EP
Citation(s) 17827287
Submission date Apr 09, 2007
Last update date Mar 17, 2012
Contact name L. Caetano M. Antunes
E-mail(s) antunes@mail.ubc.ca
Phone 604-827-3921
Organization name The University of British Columbia
Department Michael Smith Laboratories
Lab Finlay Lab
Street address #367 - 2185 East Mall
City Vancouver
State/province BC
ZIP/Postal code V6T 1Z4
Country Canada
 
Platforms (1)
GPL5074 Custom Vibrio fischeri GeneChip Array (Affymetrix)
Samples (8)
GSM181342 Vibrio fischeri cells grown to an OD600 of 0.3 with no exogenous 3OC6-HSL added #1
GSM181344 Vibrio fischeri cells grown to an OD600 of 0.3 with no exogenous 3OC6-HSL added #2
GSM181346 Vibrio fischeri cells grown to an OD600 of 0.3 with exogenous 3OC6-HSL added #1
Relations
BioProject PRJNA100301

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Supplementary file Size Download File type/resource
GSE7485_RAW.tar 22.3 Mb (http)(custom) TAR (of CEL)

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