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Series GSE75484 Query DataSets for GSE75484
Status Public on Jan 01, 2017
Title Effect of PD-1 immune checkpoint in Alzheimer's disease transgenic mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We examined the brain's choroid plexus and myeloid cell populations isolated from the brain of 5XFAD Alzheimer's disease transgenic mice following PD-1 blockade
Overall design Choroid plexus samples and myeloid cell populations were isolated from the brain of 5XFAD mice following PD-1 blockade, and sequenced. For choroid plexus samples, 5 mice were treated with anti-PD-1, 5 with IgG control, and 4 were left untreated. For the myeloid cells samples, myeloid cells sorted from the brains of 5XFAD mice according to a gating strategy that seperate microglia (CD11b+CD45-low) and monocytes-derived macrophages (CD11b+CD45-high).
Contributor(s) Baruch K, David E
Citation(s) 26779813
Submission date Nov 30, 2015
Last update date Aug 08, 2023
Contact name Ido Amit
Phone 972-8-9343338
Organization name Weizmann Institute of Science
Department Immunology
Street address 234 Herzl st.
City Rehovot
ZIP/Postal code 760001
Country Israel
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (25)
GSM1956923 PD1-1_M_14
GSM1956924 PD1-2_M_14
GSM1956925 PD1-3_F_10
BioProject PRJNA304412
SRA SRP066786

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Supplementary file Size Download File type/resource
GSE75484_20150515_AD.xlsx 3.4 Mb (ftp)(http) XLSX
GSE75484_20150515_AD_exons_homer_raw.xlsx 1.6 Mb (ftp)(http) XLSX
GSE75484_20150826_exons_homer.xlsx 2.3 Mb (ftp)(http) XLSX
GSE75484_20150826_exons_homer_raw.xlsx 1.4 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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