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Series GSE7602 Query DataSets for GSE7602
Status Public on Jun 05, 2007
Title Human GBM tumor vs Normal Human DNA
Organism Homo sapiens
Experiment type Genome variation profiling by genome tiling array
Summary Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the cancer process. Here, we engineered lymphoma-prone mice with chromosomal instability to assess the utility of mouse models in cancer gene discovery and the extent of cross-species overlap in cancer-associated copy number aberrations. Integrating with targeted re-sequencing, our comparative oncogenomic studies efficiently identified FBXW7 and PTEN as commonly deleted or mutated tumor suppressors in human T-cell acute lymphoblastic leukemia/lymphoma (T-ALL). More generally, the murine cancers acquire widespread recurrent clonal amplifications and deletions targeting loci syntenic to alterations present in not only human T-ALL but also diverse tumors of hematopoietic, mesenchymal and epithelial types. These results thus support the view that murine and human tumors experience common biological processes driven by orthologous genetic events as they evolve towards a malignant phenotype. The highly concordant nature of genomic events encourages the use of genome unstable murine cancer models in the discovery of biologically relevant driver events in human cancer.
Keywords: comparative genomic hybridization
Overall design 38 human GBM samples were analyzed. Normal Human DNA was used as reference. Some samples were hybridized with dye-swap replica.
Contributor(s) Feng B, Maser R, Protopopov A, Wiedemeyer R, Brennan C, Chin L, Depinho R
Citation(s) 17515920
Submission date Apr 24, 2007
Last update date Dec 06, 2012
Contact name bin feng
Organization name dfci
Street address 44 binney street
City boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL2879 Agilent-013282 Human Genome CGH Microarray 44B (Feature number version)
Samples (38)
GSM183818 GBM_1
GSM183819 GBM_2
GSM183820 GBM_3
This SubSeries is part of SuperSeries:
GSE7615 Cancer Process Study
GSE9200 Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
BioProject PRJNA105527

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE7602_RAW.tar 610.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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