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Series GSE787 Query DataSets for GSE787
Status Public on Oct 31, 2003
Title Corticosteroid responsive genes
Organism Rattus norvegicus
Experiment type Expression profiling by SAGE
Summary Three groups of Wistar rats with different manipulated levels of corticosterone were used to identify corticosteroid-responsive genes in hippocampus:
1. rats were adrenalectomised (ADX)
2. In addition to ADX these rats were implanted with a subcutaneous pellet containing 20 mg corticosterone and 80% cholesterol (ADX + low CORT)
3. In addition to ADX and implantation of a corticosterone pellet, these rats received a subcutaneous injection with corticosterone (1 mg/kg bodyweight) three hours prior to decapitation ((ADX + low CORT) + acute high CORT).

All 3 groups of rats were decapitated three days after ADX and their hippocampus was isolated. Hippocampal RNA from 6 rats per group was pooled and used as input material for the SAGE libraries.
Keywords: parallel sample
Contributor(s) Datson N, van der Perk J, de Kloet E, Vreugdenhil E
Citation(s) 11556892
Submission date Oct 30, 2003
Last update date Mar 02, 2012
Contact name Nicole Datson
Phone (+31)71-5276222
Organization name Leiden University
Department Medical Pharmacology
Street address
City Leiden
ZIP/Postal code 2333 CC
Country Netherlands
Platforms (1)
GPL23 SAGE:10:NlaIII:Rattus norvegicus
Samples (3)
GSM12542 rat hippocampus: adrenalectomised rat (ADX)
GSM12543 rat hipocampus: ADX + low CORT
GSM12544 rat hippocampus: (ADX + low CORT)+ acute high CORT
BioProject PRJNA87755

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