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Status |
Public on Mar 01, 2018 |
Title |
Infection with Hepatitis C Virus Depends on TACSTD2, a Regulator of Claudin-1 and Occludin Highly Downregulated in Hepatocellular Carcinoma [cell line] |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Our study identifies TACSTD2 as a novel regulator of two major HCV entry factors, CLDN1 and OCLN, which is strongly downregulated in malignant hepatocytes. These results provide new insights into the complex process of HCV entry into hepatocytes and may assist in the development of more efficient cellular systems for HCV propagation in vitro.
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Overall design |
Microarrays were performed on Huh7.5 and HepG2 cell lines maintained in Dulbecco’s modified Eagle’s medium (DMEM) with 10% FBS and 2mM L-glutamine.
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Contributor(s) |
Sekhar V, Pollicino T, Diaz G, Engle RE, Alayli F, Melis M, Kabat J, Tice A, Pomerenke A, Altan-Bonnet N, Zamboni F, Lusso P, Emerson SU, Farci P |
Citation(s) |
29538454 |
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Submission date |
Feb 29, 2016 |
Last update date |
Mar 25, 2019 |
Contact name |
Giacomo Diaz |
E-mail(s) |
gdiaz@unica.it
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Organization name |
University of Cagliari
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Department |
Dept Biomedical Sciences
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Street address |
Via Porcell 4
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City |
Cagliari |
ZIP/Postal code |
09124 |
Country |
Italy |
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Platforms (1) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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Samples (4)
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This SubSeries is part of SuperSeries: |
GSE78737 |
Infection with Hepatitis C Virus Depends on TACSTD2, a Regulator of Claudin-1 and Occludin Highly Downregulated in Hepatocellular Carcinoma |
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Relations |
BioProject |
PRJNA313407 |