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Series GSE79909 Query DataSets for GSE79909
Status Public on Oct 01, 2020
Title Gene expression analysis of serotonin transporter knock-out and wildtype rats during rat postnatal prefrontal cortex development
Organism Rattus norvegicus
Experiment type Expression profiling by high throughput sequencing
Summary To unravel the effect of increased extracellular serotonin levels on brain development, RNA-seq was performed in the medial prefrontal cortex of serotonin transporter knockout and wildtype rats at five time points from early life to adulthood (postnatal day (PND) 8, 14, 21, 35 and 70). Differential expression of protein-coding genes was analyzed and we demonstrate that a lack of functional 5-HTT especially affects gene expression in early postnatal life (PND8).
Overall design Comparison of gene expression between serotonin transporter wildtype and knockout rats at 5 different developmental time points (postnatal day 8, 14, 21, 35 and 70) in medial prefrontal cortex of Wistar rats. 5 samples per time point per genotype.
Contributor(s) Zhou J
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Submission date Apr 04, 2016
Last update date Jun 14, 2022
Contact name Jo Huiqing Zhou
Organization name Radboud University
Street address Geert Grooteplein 26/18
City Nijmegen
ZIP/Postal code 6525GA
Country Netherlands
Platforms (1)
GPL14844 Illumina HiSeq 2000 (Rattus norvegicus)
Samples (50)
GSM2108190 PFC-SERT-KO8-28-1
GSM2108191 PFC-SERT-KO8-29-4
GSM2108192 PFC-SERT-KO8-29-5
BioProject PRJNA317356
SRA SRP072848

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE79909_RAW.tar 6.7 Gb (http)(custom) TAR (of BEDGRAPH)
GSE79909_rat_KO_PFC_FPKM_table.txt.gz 1.9 Mb (ftp)(http) TXT
GSE79909_rat_WT_PFC_FPKM_table.txt.gz 1.9 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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