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| Status |
Public on Aug 25, 2017 |
| Title |
Tet-mediated DNA hydroxymethylation regulates retinal neurogenesis in zebrafish via cell-extrinsic signaling pathways |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Using zebrafish tet2-/-;tet3-/- mutants, we identify functions for Tet enzymes and 5-hydroxymethylcytosine (5hmC) in regulating gene expression and cell type-specific differentiation during retinal development.
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| |
|
| Overall design |
RNAseq from tet2-/-;tet3-/- mutant and sibling embryonic eye tissues dissected at 72hpf and 36hpf.
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| |
|
| Contributor(s) |
Seritrakul P, Gross J |
| Citation(s) |
28926578 |
| |
| Submission date |
Apr 11, 2016 |
| Last update date |
Mar 27, 2020 |
| Contact name |
Jeffrey M Gross |
| Organization name |
University of Pittsburgh
|
| Department |
Ophthalmology
|
| Lab |
Gross
|
| Street address |
3501 Fifth Avenue
|
| City |
Pittsburgh |
| State/province |
Pennsylvania |
| ZIP/Postal code |
15217 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL18413 |
Illumina HiSeq 2500 (Danio rerio) |
| GPL20828 |
Illumina NextSeq 500 (Danio rerio) |
|
| Samples (4)
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| Relations |
| BioProject |
PRJNA318016 |
| SRA |
SRP073099 |
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