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Series GSE8164 Query DataSets for GSE8164
Status Public on Dec 24, 2008
Title Imatinib targeting of KIT-mutant oncoprotein in melanoma
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
SNP genotyping by SNP array
Summary Metastatic melanoma is an aggressive treatment-refractory malignancy. Recently, c-Kit mutations were discovered in certain mucosal melanomas. A clinical trial was initiated with the c-Kit inhibitor imatinib mesylate. The first treated patient experienced dramatic clinical improvement within days, followed by major responses by PET/CT four weeks later at all sites of metastatic disease. Several established mucosal melanoma cell lines exhibited imatinib sensitivity in a fashion correlating with c-Kit mutational status. Although c-Kit mutations are uncommon in cutaneous melanoma, they may arise in geographically distinct subsets for whom use of c-Kit targeted kinase inhibition should be considered in a rational therapeutic approach.
Keywords: Whole genome copy number analysis
 
Overall design Copy number analysis using high-density SNP arrays to investigate genetic gains and losses involved in the genesis of mucosal and cutaneous melanoma.

GSE8164_raw_copy_number_calls.xls contains raw copy number calls generated by dChip (build 5/2007) for GIST, K008, K029, M34, MEL1, MEL40, M6, and 5 Affymetrix controls (copy number identity 2 i.e. normal), which are available on the HapMAP site.
 
Contributor(s) Hodi SF, Zhou J, Yuen NK, Friedlander P, Corless C, Heinrich MC, Jiang X, Mac Rae S, Kruse A, Jagannathan J, van den Abbeele A, Velazquez E, Fletcher J, Widlund HR, Demetri G, Fisher DE
Citation(s) 19047099
Submission date Jun 18, 2007
Last update date Aug 21, 2013
Contact name Stephen Hodi
E-mail(s) Stephen_Hodi@dfci.harvard.edu
Phone 1-617-632-5053
Fax 1-617-582-7992
Organization name Dana-Farber Cancer Institute
Department Medical Oncology
Street address 44 Binney Street
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
 
Platforms (1)
GPL3720 [Mapping250K_Sty] Affymetrix Mapping 250K Sty2 SNP Array
Samples (7)
GSM202003 GIST
GSM202004 K008
GSM202032 K029
Relations
BioProject PRJNA101057

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE8164_RAW.tar 197.7 Mb (http)(custom) TAR (of CEL)
GSE8164_raw_copy_number_calls.xls 38.6 Mb (ftp)(http) XLS
Processed data included within Sample table
Processed data are available on Series record

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