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| Status |
Public on Aug 10, 2016 |
| Title |
microRNA expression signatures for colon cancer initiating cell in CRC |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
In CCICs, G9a expression significantly increases K-RAS protein expression but has no effect on mRNA level. This raises the question of whether microRNA (miRNA) is involved in regulation. A heat map of a miRNA array in G9a versus shG9a transfectants ranked the Let-7 family first, with only Let-7b consistently up-regulated in G9a-knockdown CCICs and down-regulated in G9a-overexpressed non-CCICs
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| Overall design |
microRNA array in CRC clinical patient–derived cell line transfected with shRNA against G9a (CCICs/shG9a) or DN-G9a (CCICs/DN-G9a), or in non-CCICs transfected with G9a-expression vector (non-CCICs/G9a).
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| |
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| Contributor(s) |
Cha S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jun 01, 2016 |
| Last update date |
Oct 29, 2018 |
| Contact name |
SHIH-TING CHA |
| Organization name |
National Taiwan University
|
| Street address |
6F., No.2, Syu-jhou Road,
|
| City |
TAIPEI |
| ZIP/Postal code |
886 |
| Country |
Taiwan |
| |
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| Platforms (1) |
| GPL15018 |
Agilent-031181 Unrestricted_Human_miRNA_V16.0_Microarray 030840 (Feature Number version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA324110 |
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