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| Status |
Public on Aug 21, 2018 |
| Title |
Chromosomal aberrations associated with sequential steps of the metastatic cascade in colorectal cancer patients |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
|
| Summary |
Genomic profiling of primary colorectal carcinomas was performed in relation to the spread of CTCs in peripheral and hepatic venous blood,
liver metastases, and distant metastases beyond the liver, with the intent to identify specific patterns for the different stages of metastatic spread.
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| |
|
| Overall design |
DNA from primary colorectal tumors was processed according to manufacturers’ protocol (Infinium Assay, Illumina) and hybridized to Illumina Human 610-quad bead-chip, containing 610,000 probes covering the whole genome. Spot intensities were measured using the Illumina Bead Array Reader. Log transformed intensity measurements were processed by circular binary segmentation (CBS) algorithm (Matlab R2015a, The MathWorks) to identify chromosomal aberrations.
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| |
|
| Contributor(s) |
Joosse SA |
| Citation(s) |
30030273 |
| |
| Submission date |
Jun 03, 2016 |
| Last update date |
Aug 21, 2018 |
| Contact name |
Simon A Joosse |
| E-mail(s) |
s.joosse@in-silico.net
|
| Organization name |
University Medical Center Hamburg-Eppendorf
|
| Department |
Institute of Tumor Biology
|
| Street address |
Martinistrasse 52
|
| City |
Hamburg |
| ZIP/Postal code |
20246 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL8887 |
Illumina Human610-Quad v1.0 BeadChip |
|
| Samples (53)
|
|
| Relations |
| BioProject |
PRJNA324404 |
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