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Series GSE83227 Query DataSets for GSE83227
Status Public on Jun 11, 2016
Title caArray_meyer-00191: Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We have generated a molecular taxonomy of lung carcinoma, the leading cause of cancer death in the United States and worldwide. Using oligonucleotide microarrays, we analyzed mRNA expression levels corresponding to 12,600 transcript sequences in 186 lung tumor samples, including 139 adenocarcinomas resected from the lung. Hierarchical and probabilistic clustering of expression data defined distinct subclasses of lung adenocarcinoma. Among these were tumors with high relative expression of neuroendocrine genes and of type II pneumocyte genes, respectively. Retrospective analysis revealed a less favorable outcome for the adenocarcinomas with neuroendocrine gene expression. The diagnostic potential of expression profiling is emphasized by its ability to discriminate primary lung adenocarcinomas from metastases of extra-pulmonary origin. These results suggest that integration of expression profile data with clinical parameters could aid in diagnosis of lung cancer patients.
Overall design meyer-00191
Assay Type: Gene Expression
Provider: Affymetrix
Array Designs: HG_U95Av2
Organism: Homo sapiens (ncbitax)
Material Types: total RNA, synthetic_RNA, organism_part, whole_organism
Disease States: lung cancer, Normal
Citation(s) 11707567
Submission date Jun 10, 2016
Last update date Dec 13, 2018
Contact name Mervi Heiskanen
Phone 2402765175
Organization name NCI
Department CBIIT
Street address 9609 Medical Center Drive, 1W378
City Rockville
State/province MD
ZIP/Postal code 20850
Country USA
Platforms (1)
GPL8300 [HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Samples (254)
GSM2196610 meyer-00191: SQ1174
GSM2196611 meyer-00191: 295T1
GSM2196612 meyer-00191: 230T1
BioProject PRJNA325305

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE83227_RAW.tar 718.0 Mb (http)(custom) TAR (of CEL, RPT, TXT)
GSE83227_caArray_meyer-00191.tar.gz 1.3 Mb (ftp)(http) TAR
Processed data provided as supplementary file
Processed data are available on Series record

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