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Series GSE84210 Query DataSets for GSE84210
Status Public on Jun 30, 2017
Title BET inhibitors suppress BZLF1 expression [MutuI DNA-seq]
Organisms Homo sapiens; human gammaherpesvirus 4
Experiment type Other
Summary Lytic infection by the Epstein-Barr virus (EBV) poses numerous health risks, such as infectious mononucleosis and lymphoproliferative disorder. We demonstrate that JQ1 and other BET inhibitors block two different steps in the sequential cascade of the EBV life cycle: expression of the immediate-early gene BZLF1 and lytic genome replication. This represents a novel mode of action for antiviral drugs that may increase efficacy and decrease emergence of resistance. The sequenced total DNA data in this series show that JQ1 causes a decrease in EBV genome replication upon antibody induction.
 
Overall design Total DNA-seq from MutuI pretreated with JQ1 or vehicle, treated with antibody or vehicle, experiment performed in triplicate
 
Contributor(s) Keck KM, Miranda JL
Citation(s) 28588024
Submission date Jul 10, 2016
Last update date May 15, 2019
Contact name JJ Miranda
E-mail(s) jmiranda@barnard.edu
Organization name Barnard College, Columbia University
Street address 3009 Broadway
City New York
ZIP/Postal code 10027
Country USA
 
Platforms (1)
GPL22131 Illumina HiSeq 2500 (Homo sapiens; Human herpesvirus 4)
Samples (12)
GSM2229420 TotalDNA-seq_MutuI+vehicle_Replicate1
GSM2229421 TotalDNA-seq_MutuI+vehicle_Replicate2
GSM2229422 TotalDNA-seq_MutuI+vehicle_Replicate3
This SubSeries is part of SuperSeries:
GSE84214 BET inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps
Relations
BioProject PRJNA328392
SRA SRP078213

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE84210_MutuTotalDNAseqEBVQuantitation.xlsx 19.1 Kb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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