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Series GSE84759 Query DataSets for GSE84759
Status Public on Dec 31, 2016
Title LIM-Domain-Binding 1 maintains the terminally-differentiated state of pancreatic β-cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary Utilize high-throughput transcriptomic and cistromic analysis to determine the functional requirement for LDB1 and ISL1 in mature murine pancreatic β-cells while simultaneously assessing their functional interdependence at the chromatin level.
 
Overall design The total RNA profiles for FACS-enriched populations of WT, Ldb1-negative, and Isl1-negative β-cells isolated from tamoxifen-induced male mice at post-natal day (P) 56, P56, and P49, respectively, were generated by RNA-seq. The LDB1 and ISL1 whole pancreatic islet cistromes from 8-10-week-old male CD1 mice were generated by ChIP-seq.
 
Contributor(s) Ediger BN, Lim H, Won K, Stoffers DA
Citation(s) 27941246
Submission date Jul 24, 2016
Last update date May 05, 2022
Contact name Hee-Woong Lim
Organization name Cincinnati Children's Hospital Medical Center
Department Division of Biomedical Informatics
Street address 3333 Burnet Ave. MLC 7024
City Cincinnati
State/province Ohio
ZIP/Postal code 45229
Country USA
 
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (21)
GSM2249795 ChIP-seq, Islet_Ldb1
GSM2249796 ChIP-seq, Islet_Isl1
GSM2249797 ChIP-seq, Islet_Input
Relations
BioProject PRJNA331049
SRA SRP079557

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE84759_RAW.tar 1.3 Gb (http)(custom) TAR (of BED, BW)
GSE84759_RNAseq.edgeR.xlsx.gz 6.4 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Processed data are available on Series record
Processed data provided as supplementary file
Raw data are available in SRA

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