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Series GSE8510 Query DataSets for GSE8510
Status Public on Aug 01, 2007
Title RARĪ±-PLZF overcomes PLZF-mediated repression of CRABPI contributing to retinoid resistance in t(11;17) APL
Organism Homo sapiens
Experiment type Expression profiling by array
Summary This study supports an active role for PLZF and RARĪ±-PLZF in leukemogenesis, identifies upregulation of CRABPI as a novel mechanism contributing to retinoid resistance and reveals the ability of the reciprocal fusion gene products to mediate distinct
epigenetic effects contributing to the leukemic phenotype.
Keywords: Disease state analysis
Overall design 5 patients with t(11;17) or t(7;17) translocations and with the RARA-PLZF status known were analysed for changes in expression related to the reciprocal status. This is a rare disease.
Contributor(s) Guidez F, Parks S, Wong H, Jovanovic J, Mays A, Gilkes AF, Mills KI, Guillemin M, Pandolfi P, de The H, Solomon E, Grimwade D
Citation(s) 18000064
Submission date Jul 18, 2007
Last update date Aug 10, 2018
Contact name Ken Mills
Phone +442890972786
Organization name Queens University Belfast
Department CCRCB
Street address 97 Lisburn Road
City Belfast
ZIP/Postal code BT9 7BL
Country United Kingdom
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (5)
GSM211182 Patient 1
GSM211183 Patient 2
GSM211184 Patient 3
BioProject PRJNA101625

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE8510_RAW.tar 47.1 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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