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| Status |
Public on Aug 10, 2016 |
| Title |
Expression in liver tissue of wildtype (wt) or hepatocyte specific Klf6 knockout (DeltaKLF6) after partial hepatectomy |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Krüppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. Loss or reduction of KLF6 is linked with progression of experimental and human hepatocellular carcinoma. Despite its important contributions to liver homeostasis and growth, there are no data characterizing the involvement of KLF6 to hepatic regeneration.
Microarray data from wildtype and DeltaKlf6 mice were used to identify regulating mechanisms and potential mediators within liver regeneration
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| Overall design |
Wildtype and hepatocyte specific Klf6 knockout mice (DeltaKlf6) were employed for 70% partial liver resection/hepatectomy (PHx) in order to analyse liver regeneration. Twelve hours after partial hepatectomy animals were scrificed and remnant liver tissue was used for further experiemnts. For the overall study we used 6 animals per group, and included RNA from liver tissue of 3 wildtype and 3 DeltaKlf6 animals for the microarray analysis. Wildtype animals were used as controls.
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| Contributor(s) |
Bechmann LP, Sydor S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Aug 09, 2016 |
| Last update date |
Aug 06, 2018 |
| Contact name |
Lars P Bechmann |
| Organization name |
University Hospital Essen
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| Department |
Gastroenterology and Hepatology
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| Street address |
Hufelandstr. 55
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| City |
Essen |
| ZIP/Postal code |
45147 |
| Country |
Germany |
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| Platforms (1) |
| GPL11180 |
[HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate |
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| Samples (6)
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| GSM2266050 |
mouse liver, DeltaKlf6, 12h after PHx_1 |
| GSM2266051 |
mouse liver, DeltaKlf6, 12h after PHx_2 |
| GSM2266052 |
mouse liver, DeltaKlf6, 12h after PHx_3 |
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| Relations |
| BioProject |
PRJNA338305 |
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