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Series GSE85381 Query DataSets for GSE85381
Status Public on Aug 10, 2016
Title Expression in liver tissue of wildtype (wt) or hepatocyte specific Klf6 knockout (DeltaKLF6) after partial hepatectomy
Organism Mus musculus
Experiment type Expression profiling by array
Summary Kr├╝ppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. Loss or reduction of KLF6 is linked with progression of experimental and human hepatocellular carcinoma. Despite its important contributions to liver homeostasis and growth, there are no data characterizing the involvement of KLF6 to hepatic regeneration.
Microarray data from wildtype and DeltaKlf6 mice were used to identify regulating mechanisms and potential mediators within liver regeneration
Overall design Wildtype and hepatocyte specific Klf6 knockout mice (DeltaKlf6) were employed for 70% partial liver resection/hepatectomy (PHx) in order to analyse liver regeneration. Twelve hours after partial hepatectomy animals were scrificed and remnant liver tissue was used for further experiemnts. For the overall study we used 6 animals per group, and included RNA from liver tissue of 3 wildtype and 3 DeltaKlf6 animals for the microarray analysis. Wildtype animals were used as controls.
Contributor(s) Bechmann LP, Sydor S
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Submission date Aug 09, 2016
Last update date Aug 06, 2018
Contact name Lars P Bechmann
Organization name University Hospital Essen
Department Gastroenterology and Hepatology
Street address Hufelandstr. 55
City Essen
ZIP/Postal code 45147
Country Germany
Platforms (1)
GPL11180 [HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate
Samples (6)
GSM2266047 mouse liver, wt, 12h after PHx_1
GSM2266048 mouse liver, wt, 12h after PHx_2
GSM2266049 mouse liver, wt, 12h after PHx_3
BioProject PRJNA338305

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE85381_RAW.tar 13.2 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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