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Series GSE88736 Query DataSets for GSE88736
Status Public on Feb 22, 2017
Title Transcriptomics of environmental enrichment and cocaine using quantitative next generation sequencing
Organism Rattus norvegicus
Experiment type Expression profiling by high throughput sequencing
Summary Environmental enrichment produces a protective addiction phenotype in animal models. Gene transcription is thought to mediate this protective phenotype and has a profound influence on neuronal plasticity and psychiatric disorders. Understanding the molecular and genetic mechanisms underlying environmental enrichment may lead to novel targets for pharmacotherapeutics to treat cocaine addiction. We investigated the differential regulation of transcript levels using RNA sequencing of the rat nucleus accumbens after environmental enrichment/isolation and cocaine/saline self-administration. New functional pathways were also identified for cocaine modulation and environmental enrichment.
Overall design mRNA profiles were generated from the nucleus accumbens from enriched or isolated rats that self-administered cocaine or saline for 2 weeks, by RNA sequencing using illumina Hiseq1000.
Contributor(s) Green TA, Spratt HM, Luxon BA, Zhang Y, Kong F, Li D, Crofton EJ, Wood T, Widen S
Citation(s) 27899881, 29642012
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 DA029091 Molecular Mechanisms of Environmental Enrichment UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON Thomas Arthur Green
Submission date Oct 14, 2016
Last update date May 15, 2019
Contact name Thomas Arthur Green
Organization name University of Texas Medical Branch
Department Pharmacology and Toxicology
Street address 301 University dr.
City Galveston
State/province TX
ZIP/Postal code 77555
Country USA
Platforms (1)
GPL18469 Illumina HiSeq 1000 (Rattus norvegicus)
Samples (30)
GSM2344923 Sample 1_EC_cocaine
GSM2344924 Sample 2_EC_saline
GSM2344925 Sample 3_EC_cocaine
BioProject PRJNA348431
SRA SRP091541

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Supplementary file Size Download File type/resource
GSE88736_EC_IC_cocaine_SA_processed_data_file.xlsx 20.4 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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