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Series GSE90883 Query DataSets for GSE90883
Status Public on Sep 18, 2017
Title Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Mammals have evolved neurophysiologic reflexes such as coughing and scratching to expel invading pathogens and noxious environmental factors. It is well established that these responses are also associated with chronic inflammatory diseases such as asthma and atopic dermatitis. However, the mechanisms by which inflammatory pathways promote sensations such as itch remain poorly understood. Here, we show that the type 2 cytokines IL-4 and IL-13 directly stimulate sensory neurons and that chronic itch is dependent on neuronal IL-4Rα and JAK1 signaling. In proof-of-concept clinical studies, we further show that patients with recalcitrant chronic itch markedly improve when treated with JAK inhibitors. Thus, signaling mechanisms previously ascribed to the immune system may represent novel therapeutic targets within the nervous system. Collectively, these studies reveal an evolutionarily conserved paradigm in which the sensory nervous system employs classical immune signaling pathways to influence mammalian behavior.
Overall design RNA-sequencing of bulk ear skin from 4 adult C57Bl/6 mice treated with vehicle control (ethanol, EtOH) compared to bulk ear skin from 4 adult C57Bl/6 mice treated with 1 nmol topical calcipotriol (MC903) daily for 12 days.
Contributor(s) Oetjen LK, Kim BS
Citation(s) 28890086
Submission date Dec 05, 2016
Last update date May 15, 2019
Contact name Landon Kyle Oetjen
Organization name Washington University
Street address 660 S Euclid Avd
City St. Louis
State/province MO
ZIP/Postal code 63110
Country USA
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (8)
GSM2416953 Control Rep1
GSM2416954 Control Rep2
GSM2416955 Control Rep3
BioProject PRJNA356278
SRA SRP094566

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Supplementary file Size Download File type/resource
GSE90883_RAW.tar 21.3 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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