|
| Status |
Public on Sep 26, 2007 |
| Title |
Expression profiling of human adipose tissue in obese and lean subjects and in various clinical conditions |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
This SuperSeries is related to a manuscript published in Genome Biology. The abstract of this manuscript follows here:
Background
Investigations performed in mice and humans have acknowledged obesity as a low-grade inflammatory disease. Several molecular mechanisms have been convincingly involved in activating inflammatory processes and altering cell composition in white adipose tissue (WAT); however, the overall importance of these alterations, and their long-term impact on the metabolic functions of the WAT and on its morphology, remain unclear.
Results
Here, we analyzed the transcriptomic signature of the WAT in obese human subjects, in stable weight conditions and after weight loss following bariatric surgery. An original integrative functional genomic approach was applied to quantify relations between relevant structural and functional themes annotating differentially expressed genes, to construct a comprehensive map of transcriptional interactions defining the obese WAT. These analyses highlighted a significant up-regulation of genes and biological themes related to extracellular matrix (ECM) constituents, including members of integrins family, and suggested that these elements could play a major mediating role in a chain of interactions which connects local inflammatory phenomena to the alteration of WAT metabolic functions in obese subjects. Tissue and cellular investigations, driven by the analysis of transcriptional interactions, revealed an increased amount of interstitial fibrosis in obese WAT, associated with an infiltration of different types of inflammatory cells, and suggested that phenotypic alterations of human preadipocytes, induced by a proinflammatory environment, may lead to an excessive synthesis of ECM components.
Conclusions
This study opens new perspectives in understanding the biology of human WAT and its pathologic changes indicative of tissue deterioration, associated with the development of obesity.
This SuperSeries is composed of the SubSeries listed below.
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| Overall design |
Refer to individual Series.
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| Contributor(s) |
Henegar C, Tordjman J, Lacasa D, Clement K |
| Citation(s) |
18208606 |
| |
| Submission date |
Sep 25, 2007 |
| Last update date |
Dec 28, 2012 |
| Contact name |
Corneliu Henegar |
| E-mail(s) |
corneliu@henegar.info, flavien.jacques@upmc.fr
|
| Organization name |
Institut national de la santé et de la recherche médicale
|
| Department |
U872 Eq7
|
| Lab |
Eq7 Nutriomique
|
| Street address |
15 Rue de l'Ecole de Medecine
|
| City |
Paris |
| State/province |
Ile de France |
| ZIP/Postal code |
75005 |
| Country |
France |
| |
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| Platforms (9)
|
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| Samples (59)
|
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| This SuperSeries is composed of the following SubSeries:
|
| GSE8995 |
Gene expression specificity in relation to the main cellular fractions of the adipose tissue |
| GSE9007 |
Gene expression profiling of human adipose tissue of obese subjects in relation to bariatric surgery |
| GSE9017 |
Expression profile of human preadipocytes cultured with activated macrophages medium |
| GSE9153 |
Expression profiling of human adipose tissue in obese subjects |
|
| Relations |
| BioProject |
PRJNA102709 |
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