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Status |
Public on Dec 15, 2016 |
Title |
The Role of a Non-Canonical Splice Variant of the Helios Gene in the Differentiation of Jurkat T Lymphoblasts |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
In this study, the ectopic overexpressions of the wild-type Helios-1, non-canonical short isoforms Helios-Δ190-1186, Helios-Δ326-1431, and control in the Jurkat cells were utilized as the routine in vitro model of the T-cell acute lymphoblastic leukemia (T-ALL). We compared the microarray data for transcriptional analysis of the Jurkat cells with stable overexpression of full-length Helios-1, non-canonical short isoforms Helios-Δ190-1186, Helios-Δ326-1431, and mock transfected control.
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Overall design |
Gene expression profiling was performed on Jurkat cells stably expressing Helios-1, as well as short variants Helios-Δ190-1186 and Helios-Δ326-1431.
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Contributor(s) |
Feifei L, Yinghui L |
Citation missing |
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Submission date |
Dec 14, 2016 |
Last update date |
Mar 15, 2019 |
Contact name |
Feifei Liu |
E-mail(s) |
feifeink@hotmail.com
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Phone |
86-15822521698
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Organization name |
Nankai University
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Department |
School of Medicine
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Street address |
94 Weijin Road
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City |
Tianjin |
ZIP/Postal code |
300070 |
Country |
China |
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Platforms (1) |
GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
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Samples (4)
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GSM2429529 |
150602-150072A_MCS_(HuGene-2_0-st) |
GSM2429530 |
150602-150072A_Helios-1_(HuGene-2_0-st) |
GSM2429531 |
150602-150072A_Helios-d190-1186_(HuGene-2_0-st) |
GSM2429532 |
150602-150072A_Helios-d326-1431_(HuGene-2_0-st) |
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Relations |
BioProject |
PRJNA357501 |